van Son J A, Daniëls O, Vincent J G, van Lier H J, Lacquet L K
Department of Thoracic and Cardiac Surgery, Academic Hospital Nijmegen, The Netherlands.
Ann Thorac Surg. 1989 Oct;48(4):496-502. doi: 10.1016/s0003-4975(10)66848-8.
Between 1973 and 1987, 70 consecutive infants under-went repair of coarctation of the aorta. Age at operation was 80.0 +/- 77 days (mean +/- standard deviation); mean weight was 3.0 +/- 0.5 kg. Isolated coarctation was present in 25 patients (group 1); in 19 patients coarctation existed in association with ventricular septal defect (group 2); and in 26 patients coarctation was associated with major intracardiac defects (group 3). Subclavian flap angioplasty was performed in 19 patients and resection and end-to-end anastomosis in 51 patients. Hospital mortality was not significantly different between subclavian flap angioplasty (11%) and resection and end-to-end anastomosis (24%). Freedom from reintervention for recoarctation after 5 years was 87% in the subclavian flap angioplasty group and 95% in the group having resection and end-to-end anastomosis. Actuarial survival at 5 years was 100% for group 1, 73% for group 2, and 28% for group 3. In the subclavian flap angioplasty group, we observed detrimental effects of the sacrifice of the left subclavian artery: 1 patient had a 2.5-cm shortening of the left upper arm, and 5 others complained of claudication in the left upper limb during strenuous exercise. As no major advantage in terms of mortality and recoarctation to either technique of coarctation repair was found, and as subclavian flap angioplasty carries the possible disadvantage of late contracture of isthmic ductal tissue and possible detrimental effects on the left upper limb, resection and end-to-end anastomosis is recommended.
1973年至1987年间,连续70例婴儿接受了主动脉缩窄修复术。手术时年龄为80.0±77天(均值±标准差);平均体重为3.0±0.5千克。25例患者为单纯性主动脉缩窄(第1组);19例患者的主动脉缩窄合并室间隔缺损(第2组);26例患者的主动脉缩窄合并其他严重心脏内缺陷(第3组)。19例患者接受了锁骨下动脉瓣血管成形术,51例患者接受了切除及端端吻合术。锁骨下动脉瓣血管成形术组的医院死亡率(11%)与切除及端端吻合术组(24%)相比,差异无统计学意义。锁骨下动脉瓣血管成形术组5年后免于因再缩窄而再次干预的比例为87%,切除及端端吻合术组为95%。第1组5年的实际生存率为100%,第2组为73%,第3组为28%。在锁骨下动脉瓣血管成形术组,我们观察到牺牲左锁骨下动脉的不良影响:1例患者左上肢缩短2.5厘米,另外5例患者在剧烈运动时诉说左上肢有间歇性跛行。由于在主动脉缩窄修复术的两种技术中,未发现哪一种在死亡率和再缩窄方面有明显优势,而且锁骨下动脉瓣血管成形术存在峡部导管组织晚期挛缩的潜在缺点以及可能对左上肢产生不良影响,因此推荐采用切除及端端吻合术。