N-杂环卡宾-镍半三明治配合物作为芳基/杂芳基卤化物与芳基/杂芳基硼酸Suzuki-Miyaura 偶联反应的前催化剂。
An N-Heterocyclic Carbene-Nickel Half-Sandwich Complex as a Precatalyst for Suzuki-Miyaura Coupling of Aryl/Heteroaryl Halides with Aryl/Heteroarylboronic Acids.
机构信息
Faculty of Life Sciences, Kumamoto University , 5-1 Oe-honmachi Chuo-ku, Kumamoto 862-0973, Japan.
出版信息
J Org Chem. 2017 Jan 20;82(2):1266-1272. doi: 10.1021/acs.joc.6b02666. Epub 2017 Jan 11.
PMID:28029049
Abstract
A nickel half-sandwich complex supported by our original NHC ligand was developed as a robust precatalyst for Suzuki-Miyaura cross-coupling. The addition of PPh was a crucial element in the suppression of side reactions and in accelerating the cross-coupling reaction. By employing the optimal conditions, aryl-aryl, heteroaryl-aryl, and heteroaryl-heteroaryl couplings were achieved.
摘要
我们开发了一种由原始 NHC 配体支撑的镍半夹心配合物作为 Suzuki-Miyaura 交叉偶联的坚固预催化剂。添加 PPh 是抑制副反应和加速交叉偶联反应的关键因素。通过采用最佳条件，实现了芳基-芳基、杂芳基-芳基和杂芳基-杂芳基的偶联。
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