Zu Lingyun, Wen Ningxin, Liu Changjie, Zhao Mingming, Zheng Lemin
The Department of Cardiology, Peking University Third Hospital, Beijing 100191, China; Institute of Cardiovaslular Sciences, Peking University Health Science Center, Beijing 100191, China.
Cardiovasc Hematol Disord Drug Targets. 2018;18(1):14-16. doi: 10.2174/1871529X16666161227143644.
Recently, the treatment and prevention of ischemic cardiomyopathy is one of the emerging research topics in the cardiovascular field. Gap junction is the basic structure of cardiac electrophysiology. Connexin is the basic unit of gap junctions. Connexin43(CX43) is the most abundant member of Cx family in the heart, the normal expression of Cx43 is important for heart development, electrically coupled cardiomyocytes activities and coordination of myocardial function. The connection between Cx43 and myocardial ischemia/reperfusion or reperfusion injury has become the focus of current research.
We undertook a structured search of bibliographic database for peer-reviewed research literature using a focused review question and inclusion/exclusion criteria. The quality of retrieved papers was appraised using standard tools. The characteristics of screened papers were described, and a deductive qualitative content analysis methodology was applied to analyze the interventions and findings of included studies using a conceptual framework.
Twenty-one papers were included in the review, eight papers outlined the relationship of Cx43 and reperfusion arrhythmias. Eight papers pointed out the effect on the infarct size of Cx43.
The findings of this review confirm that Cx43 is the most abundant member of Cx family in the heart and is vital for myocardial protection during ischemia/reperfusion process and for ischemia/reperfusion injury. Many of its mechanism are still not very clear and require future research in the future.
近年来，缺血性心肌病的治疗与预防是心血管领域新兴的研究课题之一。缝隙连接是心脏电生理学的基本结构。连接蛋白是缝隙连接的基本单位。连接蛋白43（CX43）是心脏中连接蛋白家族中含量最丰富的成员，CX43的正常表达对心脏发育、心肌细胞电偶联活动及心肌功能协调至关重要。CX43与心肌缺血/再灌注或再灌注损伤之间的联系已成为当前研究的焦点。
我们使用聚焦的综述问题和纳入/排除标准，对文献数据库进行结构化检索以获取同行评审的研究文献。使用标准工具评估检索到的论文质量。描述筛选论文的特征，并应用演绎性定性内容分析方法，使用概念框架分析纳入研究的干预措施和结果。
本综述纳入21篇论文，其中8篇概述了CX43与再灌注心律失常的关系。8篇指出了CX43对梗死面积的影响。
本综述结果证实，CX43是心脏中连接蛋白家族中含量最丰富的成员，对缺血/再灌注过程中的心肌保护及缺血/再灌注损伤至关重要。其许多机制仍不太清楚，有待未来进一步研究。
