Ganzen T N, Aliaev Iu G, Iargin S V
Arkh Patol. 1989;51(7):30-8.
150 patients dying from renal cell carcinoma are studied in order to reveal the background disease, incidence and character of the nephrosclerosis and the possible morphogenetic link between nephrosclerosis and carcinoma. Renal cell carcinoma is found to develop in 82.7% of cases in the kidneys with signs of nephrosclerosis. The diffuse nephrosclerosis developing in connection with the hypertension disease, atherosclerosis, diabetes mellitus, chronic pyelonephritis, nephrolithiasis is the most important. Proliferation of the canaliculi epithelium with the appearance of undifferentiated cells are regularly found in the nephrosclerotic areas. The disturbance of the epithelium differentiation is followed by the development of dysplasia the phenotypical variants of which are similar to those of renal cell carcinoma. Adenomas are found in 11.3% of cases of renal cell carcinoma which may originate from the adenomas developing against the background of nephrosclerosis.
对150例死于肾细胞癌的患者进行研究，以揭示背景疾病、肾硬化的发病率和特征，以及肾硬化与癌之间可能的形态发生联系。发现82.7%的肾细胞癌病例发生在有肾硬化迹象的肾脏中。与高血压病、动脉粥样硬化、糖尿病、慢性肾盂肾炎、肾结石相关的弥漫性肾硬化最为重要。在肾硬化区域经常发现小管上皮细胞增殖并出现未分化细胞。上皮细胞分化紊乱后会发展为发育异常，其表型变异与肾细胞癌相似。在11.3%的肾细胞癌病例中发现腺瘤，这些腺瘤可能起源于在肾硬化背景下发展的腺瘤。
