Mieler W F, Jaffe G J, Steeves R A
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226.
Arch Ophthalmol. 1989 Oct;107(10):1524-8. doi: 10.1001/archopht.1989.01070020598048.
Hyperthermia has been combined with conventional radiation methods to achieve enhanced tumor destruction. We combined iodine 125 seeds with ferromagnetic thermoseeds in a single plaque to simultaneously deliver radiation and heat in a rabbit model of choroidal melanoma. Initially, six ferromagnetic thermoseeds were placed in parallel on a 14-mm episcleral plaque. The plaques were placed on normal rabbit eyes and on eyes containing transvitreally implanted choroidal melanoma. The heating response was assessed in both normal and tumor-containing eyes. Rigid copper-constantan and flexible Baily thermocouples were used to monitor temperature responses. The animals were subjected to an electromagnetic field of 100 kHz, with power of 1100 to 1500 W. The thermoseeds autoregulated at 48.2 degrees C. Scleral temperatures stabilized at 45.8 degrees C +/- 0.4 degrees C (SD), while temperatures at the base of the tumor stabilized at 43.6 degrees C +/- 0.1 degrees C. Ferromagnetic thermoseeds were then combined with iodine 125 seeds. Similar temperature responses were recorded, and autoradiographic findings confirmed a uniform radiation distribution. Varying the amount or type of ferromagnetic material in the thermoseeds allows the delivery of heat at virtually any temperature. Ferromagnetic hyperthermia may provide a more simplified approach over currently available methods of heat delivery.
热疗已与传统放疗方法相结合以增强肿瘤破坏效果。我们在兔脉络膜黑色素瘤模型中，将碘125种子与铁磁热种子置于单个敷贴器中，以同时传递辐射和热量。最初，将6个铁磁热种子平行放置在一个14毫米的巩膜上敷贴器上。将这些敷贴器放置在正常兔眼和含有经玻璃体植入脉络膜黑色素瘤的眼睛上。在正常眼和含肿瘤的眼中评估加热反应。使用刚性铜 - 康铜热电偶和柔性贝利热电偶监测温度反应。使动物暴露于100千赫的电磁场中，功率为1100至1500瓦。热种子自动调节至48.2摄氏度。巩膜温度稳定在45.8摄氏度±0.4摄氏度（标准差），而肿瘤底部温度稳定在43.6摄氏度±0.1摄氏度。然后将铁磁热种子与碘125种子相结合。记录到类似的温度反应，放射自显影结果证实辐射分布均匀。改变热种子中铁磁材料的量或类型可在几乎任何温度下传递热量。与目前可用的热传递方法相比，铁磁热疗可能提供一种更简化的方法。
