Mier Pablo, Andrade-Navarro Miguel A
Bioinformatics. 2017 Apr 15;33(8):1221-1223. doi: 10.1093/bioinformatics/btw790.
Homorepeats are low complexity regions consisting of repetitions of a single amino acid residue. There is no current consensus on the minimum number of residues needed to define a functional homorepeat, nor even if mismatches are allowed. Here we present dAPE, a web server that helps following the evolution of homorepeats based on orthology information, using a sensitive but tunable cutoff to help in the identification of emerging homorepeats.
dAPE can be accessed from http://cbdm-01.zdv.uni-mainz.de/∼munoz/polyx .
Supplementary data are available at Bioinformatics online.
同源重复序列是由单个氨基酸残基重复组成的低复杂性区域。目前对于定义一个功能性同源重复序列所需的最小残基数尚无共识，甚至对于是否允许错配也没有定论。在此，我们展示了dAPE，这是一个网络服务器，它基于直系同源信息，利用一个灵敏但可调节的阈值来帮助追踪同源重复序列的进化，以协助识别新出现的同源重复序列。
可通过http://cbdm-01.zdv.uni-mainz.de/∼munoz/polyx访问dAPE。
补充数据可在《生物信息学》在线获取。
