Effects of the heterosomes and maternal environments on aggressive behavior in Mus musculus.

This is a study of the offense type of aggression in males of the DBA/1Bg and C57BL/10Bg inbred strains of mice and their two reciprocal F1 hybrids. It uses three test paradigms for dyadic encounters: the homogeneous set test, an identity panel of testers, and the standard opponent test. There were no reciprocal F1 hybrid differences for any of the 12 behavioral measures of aggression in the homogeneous set test or the standard opponent test. For the panel of testers paradigm, reciprocal F1 hybrid differences occurred when the tester (opponent) was an F1 hybrid male, but not when the tester (opponent) was an RB/1 or C57BL10 male. When B10RB1F1 males were the testers (opponents), B10RB1F1 hybrid males were more aggressive than RB1B10F1 hybrid males across 10 of the 12 behavioral measures. Conversely, when RB1B10F1 males were the testers (opponents), RB1B10F1 males were more aggressive than B10RB1F1 males across 9 of the 12 behavioral measures. These results conform to the following empirical rule: A significant difference between reciprocal F1 hybrids is observed for these behavioral measures when one of the hybrids has both of its heterosomes (X and Y chromosomes) and its maternal environment identical to those of its opponent and the other hybrid has none of these identical to those of its opponent. These results are consistent with a model in which on some genetic backgrounds, but not on others, similarity of the heterosomes and maternal environments can influence the display of or response to social or other stimuli for the offense type of aggression in mice. These stimuli may be individual recognition chemosignals in urine.