Honsawek Sittisak, Kitidumrongsook Pravit, Luangjarmekorn Pobe, Pataradool Kawee, Thanakit Voranuch, Patradul Adisorn
Sittisak Honsawek, Pravit Kitidumrongsook, Pobe Luangjarmekorn, Kawee Pataradool, Adisorn Patradul, Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross SocietyBangkok 10330, Thailand.
World J Orthop. 2016 Dec 18;7(12):843-846. doi: 10.5312/wjo.v7.i12.843.
Glomus tumors are uncommon, benign, small neurovascular neoplasms derived from glomus bodies in the reticular dermis. Glomus bodies are found throughout the body to regulate body temperature and skin circulation; however, they are concentrated in the fingers and the sole of the foot. The typical presentation is a solitary nodule in the subungual or periungual area of the distal phalanx. The primary treatment of choice is surgical removal. We investigated expression of vascular endothelial growth factor (VEGF) using immunohistochemistry in glomus tumors of the fingers. All five glomus tumor samples were positive for VEGF expression. VEGF immunoreactivity was largely localized to the cytoplasm of tumor cells, suggesting a contribution of VEGF to the vascularization of glomus tumors.
血管球瘤是一种罕见的、良性的、起源于网状真皮层内血管球的小型神经血管性肿瘤。血管球遍布全身，用于调节体温和皮肤血液循环；然而，它们在手指和脚底最为密集。典型表现为远节指骨的甲下或甲周区域出现单个结节。首选的主要治疗方法是手术切除。我们采用免疫组织化学方法研究了手指血管球瘤中血管内皮生长因子（VEGF）的表达情况。所有五个血管球瘤样本的VEGF表达均呈阳性。VEGF免疫反应主要定位于肿瘤细胞的细胞质，提示VEGF在血管球瘤血管形成过程中发挥作用。
