5S核糖体RNA的既有群体在核糖体生物合成抑制过程中影响p53蛋白的稳定性。
The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition.
作者信息
Onofrillo Carmine, Galbiati Alice, Montanaro Lorenzo, Derenzini Massimo
机构信息
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, S. Orsola Hospital, 40138, Bologna, Italy.
出版信息
Oncotarget. 2017 Jan 17;8(3):4257-4267. doi: 10.18632/oncotarget.13833.
Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.
核糖体前体复合物RPL5/RPL11/5S rRNA（5S核糖核蛋白）被认为是在核糖体生物合成抑制过程中控制p53稳定性的核心MDM2抑制复合物。尽管其作用已得到明确界定，但5S核糖核蛋白组装的动态过程仍需要进一步表征。在本研究中，我们报告MDM2抑制依赖于预先存在的5S rRNA群体。
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