Alvarado Juan, Castro Ricardo
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile;Proyecto Epistemonikos, Santiago, Chile. Email:
Proyecto Epistemonikos, Santiago, Chile; Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Medwave. 2016 Dec 20;16(Suppl5):e6801. doi: 10.5867/medwave.2016.6801.
During an episode of sepsis, systemic inflammatory response phenomenon triggers a series of procoagulant mechanisms. It has been suggested that the use of activated protein C could play a role in the management of this pathology, but there is no consensus. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified seven systematic reviews covering 35 primary studies addressing the question of this article, including six randomized trials. We extracted data, combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded activated protein C in sepsis probably does not decrease the mortality rate and increases the rate of hemorrhagic events.
在脓毒症发作期间，全身炎症反应现象会引发一系列促凝机制。有人提出使用活化蛋白C可能在这种病症的治疗中发挥作用，但尚未达成共识。通过检索由筛选多个数据库维护的Epistemonikos数据库，我们确定了七项系统评价，涵盖了35项针对本文问题的原始研究，其中包括六项随机试验。我们提取数据，使用荟萃分析合并证据，并按照GRADE方法生成了结果总结表。我们得出结论，脓毒症中使用活化蛋白C可能不会降低死亡率，反而会增加出血事件的发生率。
