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甲状腺乳头状癌中最小甲状腺外侵犯的预后影响

Prognostic impact of minimal extrathyroidal extension in papillary thyroid carcinoma.

作者信息

Yin De-Tao, Yu Kun, Lu Run-Qing, Li Xianghua, Xu Jianhui, Lei Mengyuan

机构信息

Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University Key Discipline Laboratory of Clinical Medicine Henan Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.

出版信息

Medicine (Baltimore). 2016 Dec;95(52):e5794. doi: 10.1097/MD.0000000000005794.

DOI:10.1097/MD.0000000000005794
PMID:28033304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5207600/
Abstract

BACKGROUND

It is widely accepted that maximal extrathyroidal extension (ETE) plays a vital role in the prognosis of papillary thyroid carcinoma (PTC). However, there is no consensus among researchers about the meaning of minimal ETE (mETE) in PTC. Herein, we conducted a systematic review and meta-analysis to examine the role of mETE in the prognosis of PTC.

METHODS

We searched PubMed, EMBASE, and Cochrane search trials databases in English to identify studies comparing data on disease recurrence in PTC patients with mETE and those with no ETE. To summarize the data related to mETE status, risk ratios and hazard ratios adjusted for potential confounders were used to assess the number of recurrence and time-dependent risks related to mETE status, respectively.

RESULTS

According to the inclusion criteria, a total of 7951 patients from 9 studies were included. The recurrence rate in patients with mETE is significantly higher when compared with those with no ETE (risk ratio = 1.70, 95% confidence interval: 1.26-2.28, I = 56%). According to the data summarized with hazard ratios, PTC patients with mETE showed a significantly increased risk of disease recurrence.

CONCLUSION

mETE is a risk factor for poor prognosis in patients with PTC. Our innovative classification of ETE has its value in assessing the prognosis of PTC.

摘要

背景

甲状腺外最大延伸（ETE）在甲状腺乳头状癌（PTC）的预后中起至关重要的作用，这一点已被广泛认可。然而，研究人员对于PTC中最小ETE（mETE）的含义尚未达成共识。在此，我们进行了一项系统评价和荟萃分析，以研究mETE在PTC预后中的作用。

方法

我们检索了英文的PubMed、EMBASE和Cochrane检索试验数据库，以识别比较有mETE的PTC患者和无ETE的PTC患者疾病复发数据的研究。为总结与mETE状态相关的数据，分别使用调整潜在混杂因素后的风险比和风险比来评估与mETE状态相关的复发数量和时间依赖性风险。

结果

根据纳入标准，共纳入了9项研究中的7951例患者。与无ETE的患者相比，有mETE的患者复发率显著更高（风险比 = 1.70，95%置信区间：1.26 - 2.28，I = 56%）。根据用风险比总结的数据，有mETE的PTC患者疾病复发风险显著增加。

结论

mETE是PTC患者预后不良的一个危险因素。我们对ETE的创新性分类在评估PTC预后方面具有价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b66/5207600/d8853c2a8a92/medi-95-e5794-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b66/5207600/d3d8c27f9afc/medi-95-e5794-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b66/5207600/92d547d815de/medi-95-e5794-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b66/5207600/d8853c2a8a92/medi-95-e5794-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b66/5207600/d3d8c27f9afc/medi-95-e5794-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b66/5207600/92d547d815de/medi-95-e5794-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b66/5207600/d8853c2a8a92/medi-95-e5794-g004.jpg

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