Berger Justus, Oltmanns Frank, Holtkamp Martin, Bengner Thomas
Epilepsy-Center Berlin-Brandenburg, Berlin, Germany.
Epilepsy-Center Berlin-Brandenburg, Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany.
Epilepsy Behav. 2017 Jan;66:57-63. doi: 10.1016/j.yebeh.2016.11.037. Epub 2016 Dec 27.
Women outperform men in a host of episodic memory tasks, yet the neuroanatomical basis for this effect is unclear. It has been suggested that the anterior temporal lobe might be especially relevant for sex differences in memory. In the current study, we investigated whether temporal lobe epilepsy (TLE) has an influence on sex effects in learning and memory and whether women and men with TLE differ in their risk for memory deficits after epilepsy surgery. 177 patients (53 women and 41 men with left TLE, 42 women and 41 men with right TLE) were neuropsychologically tested before and one year after temporal lobe resection. We found that women with TLE had better verbal, but not figural, memory than men with TLE. The female advantage in verbal memory was not affected by temporal lobe resection. The same pattern of results was found in a more homogeneous subsample of 84 patients with only hippocampal sclerosis who were seizure-free after surgery. Our findings challenge the concept that the anterior temporal lobe plays a central role in the verbal memory advantage for women.
在一系列情景记忆任务中，女性的表现优于男性，但这种效应的神经解剖学基础尚不清楚。有人提出，颞叶前部可能与记忆中的性别差异特别相关。在当前的研究中，我们调查了颞叶癫痫（TLE）是否对学习和记忆中的性别效应有影响，以及患有TLE的女性和男性在癫痫手术后出现记忆缺陷的风险是否存在差异。177名患者（53名左侧TLE女性和41名左侧TLE男性，42名右侧TLE女性和41名右侧TLE男性）在颞叶切除术前和术后一年接受了神经心理学测试。我们发现，患有TLE的女性比患有TLE的男性有更好的言语记忆，但图形记忆并非如此。女性在言语记忆方面的优势不受颞叶切除术的影响。在术后无癫痫发作的84名仅患有海马硬化的患者组成的更同质子样本中也发现了相同的结果模式。我们的研究结果挑战了颞叶前部在女性言语记忆优势中起核心作用这一概念。
