Niemczyk Longin, Jędras Mirosław
Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska,
Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.
Wiad Lek. 2016;69(5):714-716.
Acute tubule-interstitial nephritis is a heterogeneous group of inflammatory diseases which affect renal parenchyma and tubules, mostly as a result of the immune-mediated injury. They are the important cause of acute kidney injury accounting for 5-15% of all its causes. In subsequent years, with the development of pharmacotherapy, the incidence of drug-induced nephrotoxicity has been increasing. The other causes of the acute tubule-interstitial nephritis are autoimmune and inflammatory diseases, infections, neoplasms and electrolyte abnormalities. The diagnostics are complex and treatment of the disease is not always easy. The following overview provides a summary of causes of acute tubule-interstitial nephritis, clinical picture of the disease, the diagnosis and treatment.
急性肾小管间质性肾炎是一组异质性炎症性疾病，主要由于免疫介导的损伤而影响肾实质和肾小管。它们是急性肾损伤的重要原因，占所有病因的5% - 15%。在随后的几年里，随着药物治疗的发展，药物性肾毒性的发生率一直在上升。急性肾小管间质性肾炎的其他病因包括自身免疫性和炎症性疾病、感染、肿瘤以及电解质异常。该疾病的诊断复杂，治疗也并非总是容易。以下概述总结了急性肾小管间质性肾炎的病因、疾病临床表现、诊断和治疗方法。
