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混合治疗:扩大感染性肾下腹主动脉和髂动脉瘤的治疗手段

Hybrid Treatment: Expanding the Armamentarium for Infected Infrarenal Abdominal Aortic and Iliac Aneurysms.

作者信息

Han Kichang, Lee Do Yun, Kim Man-Deuk, Lee Sak, Won Jong Yun, Kwon Joon Ho, Choi Donghoon, Ko Young-Guk

机构信息

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro Seodaemun-gu, Seoul, 120-752 Korea.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, 50 Yonsei-ro Seodaemun-gu, Seoul, 120-752 Korea.

出版信息

J Vasc Interv Radiol. 2017 Apr;28(4):564-569. doi: 10.1016/j.jvir.2016.10.028. Epub 2016 Dec 27.

Abstract

PURPOSE

To investigate safety and efficacy of hybrid treatment for infected aortic and iliac aneurysms.

MATERIALS AND METHODS

Between July 2007 and May 2011, hybrid treatment was performed in 6 male patients (mean age, 67.7 y; range, 57-76 y). Hybrid treatment consisted of extraanatomic bypass (EAB) and isolation of infected aneurysm with vascular plugs. Aneurysms were divided into primary and secondary infected aneurysms. Primary infected aneurysm refers to an aneurysm arising from bacterial infection of the native arterial wall; secondary infected aneurysm refers to infection involving an aneurysm that was previously treated with graft placement.

RESULTS

The infected aneurysm involved the infrarenal abdominal aorta in 4 patients and common iliac artery in 2 patients. Hybrid treatment was successful in all 6 patients. The 3 patients with primary infected aneurysms required only hybrid treatment, whereas infected graft excision and new graft interposition was performed in 2 of the 3 patients with secondary infected aneurysms. No 30-day mortality or complications were reported. During mean follow-up of 58.6 months (range, 32.6-75.8 months), 1 patient (17%) with a secondary infected aneurysm who did not undergo additional surgery died 32.6 months after hybrid treatment from hypovolemic shock secondary to recurrent aortoenteric fistula. Cumulative survival was 100%, 100%, 83%, and 83% at 3 months, 1 year, 3 years, and 5 years.

CONCLUSIONS

Hybrid treatment appears to be a stand-alone, curative treatment for primary infected aneurysms and serves as bridge therapy to subsequent surgery for secondary infected aneurysms.

摘要

目的

探讨杂交治疗感染性主动脉和髂动脉瘤的安全性和有效性。

材料与方法

2007年7月至2011年5月,对6例男性患者(平均年龄67.7岁;范围57 - 76岁)实施了杂交治疗。杂交治疗包括解剖外旁路术(EAB)和用血管塞隔离感染性动脉瘤。动脉瘤分为原发性和继发性感染性动脉瘤。原发性感染性动脉瘤是指由天然动脉壁细菌感染引起的动脉瘤;继发性感染性动脉瘤是指感染累及先前已行移植物植入治疗的动脉瘤。

结果

感染性动脉瘤累及肾下腹主动脉4例,髂总动脉2例。6例患者杂交治疗均成功。3例原发性感染性动脉瘤患者仅需杂交治疗,而3例继发性感染性动脉瘤患者中有2例行感染移植物切除及新移植物植入。未报告30天死亡率或并发症。平均随访58.6个月(范围32.6 - 75.8个月),1例未接受额外手术的继发性感染性动脉瘤患者在杂交治疗后32.6个月因复发性主动脉肠瘘继发低血容量性休克死亡。3个月、1年、3年和5年的累积生存率分别为100%、100%、83%和83%。

结论

杂交治疗似乎是原发性感染性动脉瘤的一种独立的根治性治疗方法,并可作为继发性感染性动脉瘤后续手术的桥接治疗。

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