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梗阻性脑积水患者重复内镜下第三脑室造瘘术的长期随访

Long-Term Follow-Up of Repeat Endoscopic Third Ventriculostomy in Obstructive Hydrocephalus.

作者信息

Oertel Joachim, Vulcu Sonja, Eickele Leonie, Wagner Wolfgang, Cinalli Giuseppe, Rediker Jana

机构信息

Department of Neurosurgery, Saarland University Medical Center, Homburg/Saar, Germany.

Department of Neurosurgery, Saarland University Medical Center, Homburg/Saar, Germany.

出版信息

World Neurosurg. 2017 Mar;99:556-565. doi: 10.1016/j.wneu.2016.12.072. Epub 2016 Dec 27.

Abstract

OBJECTIVE

Endoscopic third ventriculostomy (ETV) is a safe and less-invasive treatment strategy for patients with obstructive hydrocephalus and provides excellent outcome. Nevertheless, repeat ETV in cases of ETV failure is a controversial issue.

METHODS

Between 1993 and 1999, 113 patients underwent a total of 126 ETVs at the Department of Neurosurgery, Mainz University Hospital. Obstructive hydrocephalus was the causative pathology in all cases. A very long-term follow-up of up to 16 years could be achieved. All medical reports of patients who received ETV were reviewed and analyzed with focus on ETV failure with following repeat ETV and its initial as well as very long-term success.

RESULTS

Thirty-one events of ETV failure occurred during the follow-up period. Thirteen patients underwent repeat ETV: 3 patients during the first 3 months (early repeat ETV), the other 10 patients after 7-78 months (late repeat ETV, mean 33 months). All repeat ETV were performed without complications. Follow-up evaluation after successful repeat ETV ranged from <1 month up to 14 years (mean 7 years). Of the 3 early revisions, 2 failed and 1 other patient died during follow-up whereas only 2 of the late repeat ETV failed. Very long-term success rate of late repeat ETV up to 14 years yielded 80%.

CONCLUSIONS

Repeat ETV in cases of late ETV failures represents an excellent option for cerebrospinal fluid circulation restoration up to 14 years of follow-up. Repeat ETV in early ETV failure in contrast is not favored by the performing surgeons; and factors of ETV failure should be analyzed very carefully before a decision for repeat ETV is made.

摘要

目的

内镜下第三脑室造瘘术(ETV)是治疗梗阻性脑积水患者的一种安全且侵入性较小的治疗策略,效果良好。然而,ETV失败后再次进行ETV是一个有争议的问题。

方法

1993年至1999年期间,美因茨大学医院神经外科共有113例患者接受了126次ETV手术。所有病例的病因均为梗阻性脑积水。随访时间长达16年。回顾并分析了所有接受ETV治疗患者的医疗报告,重点关注ETV失败后再次进行ETV的情况及其初始和长期成功率。

结果

随访期间发生了31次ETV失败事件。13例患者接受了再次ETV手术:3例在最初3个月内(早期再次ETV),另外10例在7 - 78个月后(晚期再次ETV,平均33个月)。所有再次ETV手术均无并发症。再次ETV成功后的随访评估时间从不到1个月至14年不等(平均7年)。在3例早期翻修手术中,2例失败,另1例患者在随访期间死亡,而晚期再次ETV手术仅有2例失败。晚期再次ETV长达14年的长期成功率为80%。

结论

晚期ETV失败后再次进行ETV是恢复脑脊液循环长达14年随访的极佳选择。相比之下,早期ETV失败后再次进行ETV并不受手术医生青睐;在决定再次进行ETV之前,应非常仔细地分析ETV失败的因素。

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