新加坡一家三级转诊眼科护理中心疑似结核性葡萄膜炎患者的治疗结果
Treatment outcome in patients with presumed tubercular uveitis at a tertiary referral eye care centre in Singapore.
作者信息
Ang Leslie, Kee Aera, Yeo Tun Hang, Dinesh V G, Ho Su Ling, Teoh Stephen C, Agrawal Rupesh
机构信息
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
出版信息
Int Ophthalmol. 2018 Feb;38(1):11-18. doi: 10.1007/s10792-016-0401-6. Epub 2016 Dec 29.
AIM
To report the clinical features and outcome of patients with presumed tubercular uveitis (TBU).
METHODS
Retrospective analysis of patients with presumed TBU at a tertiary referral eye care centre in Singapore between 2007 and 2012 was done. Main outcome measures were failure of complete resolution of uveitis or recurrence of inflammation.
RESULTS
Fifty three patients with mean age of 44.18 ± 15.26 years with 54.72% being males were included. 19 (35.85%) had bilateral involvement, with panuveitis and anterior uveitis being the most common presentations. 36 (67.92%) patients received antitubercular therapy (ATT), and 28 received concurrent systemic steroids. 15 (28.30%) eyes of 11 (30.55%) patients in the ATT group and 4 (21.05%) eyes of 3 (17.64%) patients in the non-ATT group had treatment failure (p value = 0.51).
CONCLUSION
The use of ATT, with or without concurrent corticosteroid, may not have a statistically significant impact in improving treatment success in patients with presumed TBU.
目的
报告疑似结核性葡萄膜炎（TBU）患者的临床特征及预后。
方法
对2007年至2012年期间新加坡一家三级转诊眼科护理中心的疑似TBU患者进行回顾性分析。主要观察指标为葡萄膜炎完全消退失败或炎症复发。
结果
纳入53例患者，平均年龄44.18±15.26岁，男性占54.72%。19例（35.85%）为双侧受累，全葡萄膜炎和前葡萄膜炎是最常见的表现。36例（67.92%）患者接受了抗结核治疗（ATT），28例接受了全身类固醇联合治疗。ATT组11例（30.55%）患者的15只眼（28.30%）及非ATT组3例（17.64%）患者的4只眼（21.05%）治疗失败（p值=0.51）。
结论
使用ATT（无论是否联合皮质类固醇）对提高疑似TBU患者的治疗成功率可能没有统计学上的显著影响。
Zotero 插件