Malviya Neeta, Rainwater Yevgeniya B, Vandergriff Travis, Mauskar Melissa M
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
J Cutan Pathol. 2017 Mar;44(3):296-299. doi: 10.1111/cup.12885. Epub 2017 Feb 2.
We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angiocentric and dermal proliferation of markedly atypical lymphoid cells with numerous mitoses and apoptotic bodies along with broad zones of necrosis. Biopsy revealed the presentation to be consistent with NK/T-cell lymphoma. The cutaneous lesions from NK/T-cell lymphoma can often be initially mistaken for cellulitis, therefore this malignancy should be included on the differential in a patient HIV/acquired immune deficiency syndrome (AIDS).
我们报告一例28岁男性病例，该患者有人类免疫缺陷病毒（HIV）感染史，右后肩部有一持续增大、质地硬且疼痛的病变，病程1个月。鉴于其临床表现，患者最初接受了蜂窝织炎治疗。组织病理学检查显示，真皮层有以血管为中心的显著非典型淋巴细胞增殖，伴有大量有丝分裂和凋亡小体，以及大片坏死区域。活检显示该表现符合NK/T细胞淋巴瘤。NK/T细胞淋巴瘤的皮肤病变最初常被误诊为蜂窝织炎，因此在HIV/获得性免疫缺陷综合征（AIDS）患者的鉴别诊断中应考虑到这种恶性肿瘤。
