Cole G C, Wilkins P R, West R R
Department of Pathology, University of Wales College of Medicine, Cardiff, United Kingdom.
Br J Neurosurg. 1989;3(4):487-93. doi: 10.3109/02688698909002835.
This survey is founded on 526 patients who presented with a primary tumour of the brain, spinal cord or their coverings over a seven year period. The patients resided in one of the three counties comprising South East Wales, which has a population of about 1.3 million. Each tumour type is classified according to age, sex and area of residence of the patient. Age and sex adjusted annual incidence rates were calculated for each tumour type. All types of glioma have a higher incidence in males, while meningiomas are twice as common in females. Gliomas are the most commonly occurring tumour with an average annual incidence of 3.6 per 100,000 and a peak incidence for malignant astrocytomas of 7.6 in the 55 to 64 year age group. The low grade astrocytoma is the most common tumour of childhood. Oligodendrogliomas occur most commonly in adults between the ages of 35 and 44 years. In this survey there is an unexplained relatively high incidence of oligodendrogliomas. The majority of primary tumours arose in the brain, but there were 24 tumours of the spinal cord, nerve sheath and meninges. Comment is made on the presence and possible aetiological significance of chemical industries within South East Wales.
这项调查基于526名患者，这些患者在七年时间里出现了原发性脑肿瘤、脊髓肿瘤或其被膜肿瘤。患者居住在构成东南威尔士的三个县之一，该地区人口约130万。每种肿瘤类型都根据患者的年龄、性别和居住地区进行分类。计算了每种肿瘤类型的年龄和性别调整后的年发病率。所有类型的胶质瘤在男性中的发病率都较高，而脑膜瘤在女性中的发病率是男性的两倍。胶质瘤是最常见的肿瘤，平均年发病率为每10万人3.6例，恶性星形细胞瘤的发病率在55至64岁年龄组达到峰值，为每10万人7.6例。低级别星形细胞瘤是儿童最常见的肿瘤。少突胶质细胞瘤最常发生在35至44岁的成年人中。在这项调查中，少突胶质细胞瘤的发病率相对较高，原因不明。大多数原发性肿瘤发生在脑部，但有24例发生在脊髓、神经鞘和脑膜。文中对东南威尔士化学工业的存在及其可能的病因学意义进行了评论。
