通过高密度脂蛋白2（HDL2）与头状葡萄球菌提取物之间的沉淀反应估计冠心病患者和对照组的血清HDL2分布。

Serum HDL2 distribution in patients with coronary heart disease and controls as estimated by a precipitation reaction between HDL2 and an extract of Staphylococcus capitis.

作者信息

Osland A, Høstmark A T, Simonsen S, Levorstad K

机构信息

Department of Preventive Medicine, University of Oslo, Norway.

出版信息

APMIS. 1989 Oct;97(10):923-5. doi: 10.1111/j.1699-0463.1989.tb00499.x.

DOI:10.1111/j.1699-0463.1989.tb00499.x

PMID:2803754

Abstract

Serum HDL2 concentration has been shown to be lowered in patients with coronary heart disease (CHD). Since we previously reported that serum HDL2 can be estimated by single radial diffusion in agar containing an extract of Staphylococcus capitis, it seemed of interest to study whether serum HDL2 as estimated by this method is different in CHD patients and controls. It was shown that relative activity of HDL2, assessed by the method, was appreciably lower in 40 men with angiographically proven coronary artery disease (CAD) than in a control group of 39 men of the same age. Also apolipoprotein A (apo A) concentration was lower in the CAD group, but group difference in HDL2 activity was greater than separation based upon apoA. It is suggested that precipitation with an extract of Staphylococcus capitis might be a useful approach to estimate serum HDL2 levels.

摘要

血清高密度脂蛋白2（HDL2）浓度在冠心病（CHD）患者中已被证明会降低。由于我们之前报道过血清HDL2可以通过在含有头状葡萄球菌提取物的琼脂中进行单向扩散来估算，因此研究通过这种方法估算的血清HDL2在冠心病患者和对照组中是否存在差异似乎很有意义。结果表明，在40名经血管造影证实患有冠状动脉疾病（CAD）的男性中，通过该方法评估的HDL2相对活性明显低于39名同龄男性组成的对照组。CAD组中的载脂蛋白A（apo A）浓度也较低，但HDL2活性的组间差异大于基于apoA的差异。提示用头状葡萄球菌提取物沉淀可能是估算血清HDL2水平的一种有用方法。