Wang Yan, Chen Bo Zhi, Liu Yue Jin, Wu Zhi Min, Guo Xin Dong
School of Chemical Engineering, Xiangtan University, Xiangtan 411105, PR China; Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Colloids Surf B Biointerfaces. 2017 Mar 1;151:280-286. doi: 10.1016/j.colsurfb.2016.12.027. Epub 2016 Dec 20.
The pH-sensitive nanoparticles are selected as the potentially promising oral protein and peptide drug carriers due to their excellent performance. With the poly (lactic-co-glycolic acid)/hydroxypropyl methylcellulose phthalate (PLGA/HP55) nanoparticle as a model nanoparticle, the structure-property relationship of nanoparticles with different conditions is investigated by dissipative particle dynamics (DPD) simulations in our work. In the oral drug delivery system, the poly (lactic-co-glycolic acid) (PLGA) is hydrophobic polymer, hydroxypropyl methylcellulose phthalate (HP55) is pH-sensitive enteric polymer which used to protect the nanoparticles through the stomach and polyvinyl alcohol (PVA) is hydrophilic polymer as the stabilizer. It can be seen from DPD simulations that all polymer molecules form spherical core-shell nanoparticles with stabilizer PVA molecules adsorbed on the outer surface of the PLGA/HP55 matrix at certain compositions. The DPD simulation study can provide microscopic insight into the formation and morphological changes of pH-sensitive nanoparticles which is useful for the design of new materials for high-efficacy oral drug delivery.
由于其优异的性能，pH敏感纳米颗粒被选为潜在的有前景的口服蛋白质和肽类药物载体。在我们的工作中，以聚（乳酸-乙醇酸）/邻苯二甲酸羟丙基甲基纤维素（PLGA/HP55）纳米颗粒为模型纳米颗粒，通过耗散粒子动力学（DPD）模拟研究了不同条件下纳米颗粒的结构-性能关系。在口服给药系统中，聚（乳酸-乙醇酸）（PLGA）是疏水性聚合物，邻苯二甲酸羟丙基甲基纤维素（HP55）是pH敏感型肠溶聚合物，用于保护纳米颗粒通过胃部，聚乙烯醇（PVA）是作为稳定剂的亲水性聚合物。从DPD模拟可以看出，在特定组成下，所有聚合物分子都形成了球形核壳纳米颗粒，稳定剂PVA分子吸附在PLGA/HP55基质的外表面。DPD模拟研究可以为pH敏感纳米颗粒的形成和形态变化提供微观见解，这对于高效口服给药新材料的设计是有用的。
