Jiang Yongjun, Zhai Qijin, Dai Zheng, Xu Xiaomeng, Xu Xiaohui, Wen Zhuoyu, Liu Xinfeng
Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nanjing 210002, China.
Department of Neurology, Jinling Hospital, Southern Medical University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China; Department of Neurology, The Second People's Hospital of Huai'an and The Affiliated Huai'an Hospital of Xuzhou Medical University, 60 South Huaihai Road, Huai'an, Jiangsu, China.
Int J Cardiol. 2017 Mar 1;230:103-107. doi: 10.1016/j.ijcard.2016.12.070. Epub 2016 Dec 21.
Multicenter randomized controlled trials are the core of evidence-based medicine. Our study aimed to investigate the key factor which determined the outcome of the multicenter randomized controlled trials.
We searched publications in PubMed for multicenter randomized controlled trials reporting primary data on treating and preventing cardiovascular diseases circulation area. The data were extracted from the including trials and used for analysis.
A total of 1075 trials for treating and preventing cardiovascular diseases were included, of which 979 were involved in the heart diseases and 96 involved in stroke. The execution time significantly contributed to the outcome of trials with shorter time related to significant outcome. However, the numbers of participated centers and their locations and participants had no effect on the outcome of trials. Moreover, the number of centers showed no significant relationship with execution time.
Execution time but not centers or participants contributed to the outcome of multicenter randomized controlled trials.
多中心随机对照试验是循证医学的核心。我们的研究旨在调查决定多中心随机对照试验结果的关键因素。
我们在PubMed上搜索关于治疗和预防心血管疾病循环领域的多中心随机对照试验的出版物，报告原始数据。从纳入的试验中提取数据并进行分析。
共纳入1075项治疗和预防心血管疾病的试验，其中979项涉及心脏病，96项涉及中风。执行时间对试验结果有显著影响，时间越短，结果越显著。然而，参与中心的数量、其地理位置和参与者对试验结果没有影响。此外，中心数量与执行时间没有显著关系。
对多中心随机对照试验结果有影响的是执行时间，而非中心或参与者。
