黄酮醋酸在晚期恶性黑色素瘤和结直肠癌中的II期试验。
Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma.
作者信息
Kerr D J, Maughan T, Newlands E, Rustin G, Bleehen N M, Lewis C, Kaye S B
机构信息
CRC Department of Medical Oncology, University of Glasgow, UK.
出版信息
Br J Cancer. 1989 Jul;60(1):104-6. doi: 10.1038/bjc.1989.230.
Abstract
Flavone acetic acid (FAA), 8.6 gm-2 has been administered by 6h intravenous infusion to 19 patients with advanced colorectal carcinoma and 15 patients with advanced malignant melanoma. The drug associated toxicity was generally mild and as predicted from the phase I study. No responses were seen in either disease.
摘要
已对19例晚期结肠癌患者和15例晚期恶性黑色素瘤患者进行了静脉输注，以每6小时8.6克/平方米的剂量给予黄酮醋酸（FAA）。药物相关毒性一般较轻，与I期研究预测的情况相符。两种疾病均未见缓解。
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Cancer Treat Rep. 1986 Dec;70(12):1415-21.
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