Kadletz Lorenz, Heiduschka Gregor, Wiebringhaus Robert, Gurnhofer Elisabeth, Kotowski Ulana, Haymerle Georg, Brunner Markus, Barry Conor, Kenner Lukas
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
Department of Pathology, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Cell Oncol (Dordr). 2017 Apr;40(2):193-198. doi: 10.1007/s13402-016-0310-8. Epub 2016 Dec 30.
Previously, the engulfment and cell motility 3 (ELMO3) protein has been reported to be involved in cell migration and cytoskeletal remodeling. As of yet, nothing is known about the role of ELMO3 in head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to asses ELMO3 expression in postoperatively irradiated HNSCC patients and to evaluate a possible correlation between this expression and patient survival.
125 postoperatively irradiated HNSCC patients were included in this study. ELMO3 expression was assessed using immunohistochemistry (IHC). The expression of ELMO3 in the respective HNSCC tumor tissues and its lymph node metastases was correlated with patient survival using Kaplan-Meier curve analyses.
Through IHC, ELMO3 expression was detected in 71.2% of the HNSCC cases tested. We found significantly increased overall and disease-free survival rates and decreased recurrence rates in patients with no detectable ELMO3 expression. In reverse, we found that ELMO3 expression served as an independent marker for a decreased overall and disease-free survival.
Our data indicate that in the surgically treated and postoperatively irradiated patients tested, ELMO3 expression serves as a predictive marker for reduced survival.
此前，据报道吞噬与细胞运动3（ELMO3）蛋白参与细胞迁移和细胞骨架重塑。截至目前，ELMO3在头颈部鳞状细胞癌（HNSCC）中的作用尚不清楚。本研究的目的是评估ELMO3在接受术后放疗的HNSCC患者中的表达情况，并评估这种表达与患者生存率之间的可能相关性。
本研究纳入了125例接受术后放疗的HNSCC患者。采用免疫组织化学（IHC）方法评估ELMO3表达。使用Kaplan-Meier曲线分析将ELMO3在相应HNSCC肿瘤组织及其淋巴结转移灶中的表达与患者生存率进行相关性分析。
通过免疫组织化学检测，在71.2%的检测HNSCC病例中检测到ELMO3表达。我们发现，ELMO3表达未被检测到的患者的总生存率和无病生存率显著提高，复发率降低。相反，我们发现ELMO3表达是总生存率和无病生存率降低的独立标志物。
我们的数据表明，在接受手术治疗和术后放疗的患者中，ELMO3表达是生存率降低的预测标志物。
