Anandan Charenya, Khuder Sadik A, Koffman Boyd M
Department of Neurology University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, Ohio, 43614, USA.
Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.
Muscle Nerve. 2017 Aug;56(2):331-333. doi: 10.1002/mus.25551. Epub 2017 Mar 23.
There is a paucity of data regarding autonomic dysfunction (AD) in Guillain-Barré Syndrome (GBS). Concern exists regarding inpatient mortality risk in GBS. We sought to identify the prevalence of AD in GBS inpatients.
We used the Health Cost and Utilization Project Nationwide Inpatient Sample (NIS). GBS hospitalizations were identified by International Classification of Diseases, Ninth Revision, Clinical Modification code-357.0. Non-GBS hospitalizations were matched to these cases 4:1 by age and gender.
We identified 2,587 GBS patients and a control population of 10,348 patients during 2010-2011. The most common manifestations of AD were: diarrhea/constipation (15.5%), hyponatremia (14.9%), syndrome of inappropriate antidiuretic hormone secretion (SIADH) (4.8%), bradycardia (4.7%), and urinary retention (3.9%). GBS patients had higher rates of reversible cardiomyopathy, syncope, tachycardia, and Horner syndrome (P < 0.0001).
AD most commonly manifests as diarrhea/constipation, SIADH/hyponatremia, and cardiac dysfunction. This report can help increase awareness of AD in GBS and aid in early identification, treatment, and mortality reduction. Muscle Nerve 56: 331-333, 2017.
关于吉兰 - 巴雷综合征（GBS）中自主神经功能障碍（AD）的数据匮乏。人们对GBS患者的住院死亡风险存在担忧。我们试图确定GBS住院患者中AD的患病率。
我们使用了医疗成本和利用项目全国住院样本（NIS）。通过国际疾病分类第九版临床修订本代码357.0识别GBS住院病例。非GBS住院病例按年龄和性别以4:1的比例与这些病例匹配。
在2010 - 2011年期间，我们确定了2587例GBS患者和10348例对照人群。AD最常见的表现为：腹泻/便秘（15.5%）、低钠血症（14.9%）、抗利尿激素分泌不当综合征（SIADH）（4.8%）、心动过缓（4.7%）和尿潴留（3.9%）。GBS患者可逆性心肌病、晕厥、心动过速和霍纳综合征的发生率更高（P < 0.0001）。
AD最常见的表现为腹泻/便秘、SIADH/低钠血症和心脏功能障碍。本报告有助于提高对GBS中AD的认识，并有助于早期识别、治疗和降低死亡率。《肌肉与神经》56: 331 - 333, 2017年。
