Island Ecology and Evolution Research Group, Instituto de Productos Naturales y Agrobiología (IPNA-CSIC), C/Astrofísico Francisco Sánchez 3, La Laguna, Tenerife, Canary Islands, 38206, Spain.
School of Biological Sciences, Norwich Research Park, University of East Anglia, Norwich, NR4 7TJ, UK.
Mol Ecol. 2017 May;26(10):2623-2624. doi: 10.1111/mec.13951. Epub 2016 Dec 31.
We contribute to the recent review of Rieux & Balloux, 2016, Mol. Ecol., 25, 1911 on inferences from tip-dated phylogenies by developing their discussion on the influence of population size (N ) under panmixia for the estimation of substitution rate (μ). We highlight how phylogenetic trees inferred with tip-dated sequences under large panmictic N tend to erroneously enforce an age-based coalescent pattern on the posterior distribution of trees, which in turn results in systematically inflated estimates of μ. We discuss the consequences of this and suggest how to accommodate the issue in the short term and long term.
我们为 Rieux & Balloux（2016）的近期综述做出了贡献，该综述发表在《分子生态学》（Mol. Ecol.）第 25 卷第 1911 期，讨论了在泛种群下从尖端日期的系统发育推断替代率（μ）的影响。我们强调了在大型泛种群 N 下从尖端日期序列推断的系统发育树如何错误地将基于年龄的聚合并置模式强加于树的后验分布，这反过来又导致μ的系统高估。我们讨论了这个问题的后果，并提出了如何在短期和长期内解决这个问题。
