Long Bing, Cheng Lei, Lai Shu-Ping, Zhang Jing-Wen, Sun Yan-Ling, Lai Wen-Xin, Zhang Hai-Yan, Lu Ying, Lin Dong-Jun, Li Xu-Dong
Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Ophthalmology, First People's Hospital of Shenzhen, Shenzhen, China.
Clin Chim Acta. 2017 May;468:111-113. doi: 10.1016/j.cca.2016.12.028. Epub 2016 Dec 28.
Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal condition that can be primary or secondary. Secondary HLH due to Mycobacterium tuberculosis (TB) is uncommon. We report a case of tuberculosis-associated HLH in an umbilical cord blood transplant (UCBT) recipient and discuss its clinical characteristics and challenges.
Hematologic investigations, bone marrow aspirates, Xpert MTB/RIF test of TB with peripheral blood were performed. Immune modulation with anti-TB therapy was initiated.
Subsequent treatment with anti-TB treatment resulted rapid clinical response and disease remission.
It is important to consider TB as one of the underlying cause of HLH in high-risk patients, particularly those in immunodeficient states. Early diagnosis and treatment can improve the survival rates of patients with tuberculosis-associated HLH.
噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见的、可能致命的疾病，可分为原发性或继发性。由结核分枝杆菌（TB）引起的继发性HLH并不常见。我们报告了一例脐带血移植（UCBT）受者中与结核病相关的HLH病例，并讨论其临床特征和挑战。
进行了血液学检查、骨髓穿刺、外周血结核分枝杆菌Xpert MTB/RIF检测。开始采用抗结核治疗进行免疫调节。
随后的抗结核治疗导致了快速的临床反应和疾病缓解。
将结核病视为高危患者（尤其是免疫缺陷状态患者）HLH的潜在病因之一很重要。早期诊断和治疗可提高结核病相关HLH患者的生存率。
