Erasmus University Medical Center, Rotterdam, The Netherlands.
Trends Mol Med. 2017 Jan;23(1):6-17. doi: 10.1016/j.molmed.2016.11.006.
The potential to reverse aging has long been a tantalizing thought, but has equally been considered mere utopia. Recently, the spotlights have turned to senescent cells as being a culprit for aging. Can these cells be therapeutically eliminated? When so? And is this even safe? Recent developments in the tool box to study senescence have made it possible to begin addressing these questions. It will be especially relevant to identify how senescence impairs tissue rejuvenation and to prospectively design compounds that can both target senescence and stimulate rejuvenation in a safe manner. This review argues that to fulfill this niche, cell-penetrating peptides may provide promising therapeutics. As a candidate approach, the author also highlights the potential of targeting individual FOXO signaling pathways to combat senescence and stimulate tissue rejuventaion.
衰老的逆转一直以来都是一个诱人的想法，但同样也被认为是纯粹的乌托邦。最近，衰老细胞成为衰老的罪魁祸首，这一观点引起了广泛关注。这些细胞可以通过治疗手段被清除吗？如果可以，何时可以清除？并且这样做是否安全？研究衰老的工具盒中的最新进展使得我们能够开始回答这些问题。确定衰老如何损害组织再生，并前瞻性地设计既能靶向衰老又能安全刺激再生的化合物，这将尤其重要。这篇综述认为，为了满足这一需求，细胞穿透肽可能提供有前途的治疗方法。作为一种候选方法，作者还强调了靶向单个 FOXO 信号通路以对抗衰老和刺激组织再生的潜力。
