Rozental' V V, Serikov V B, Beliakov N A
Nauchnye Doki Vyss Shkoly Biol Nauki. 1989(6):62-8.
During the violation of force balance determining the fluid transport between the vascular and extravascular space a transitional unsteady process of fluid accumulation and its passing through endothelium is observed. On the basis of the experimental data obtained on isolated lungs a model for description of unsteady-state phenomena using the linear nonequilibrium thermodynamics equations is proposed. The fluid flow is characterized by simple equations as the equation of Kedem-Kachal'skiĭ type. The endothelial membrane is considered as half-permeable barrier consisting of three populations of different pores. The model includes the consideration of mechanical characteristics of interstitial space and time interstice volume change during the edema development. Besides the fluid flow from interstice into the air lung space is taking into consideration. The model numerical solution corresponds to the experimental regularities.
在决定血管和血管外空间之间液体转运的力平衡被破坏期间，观察到液体蓄积及其通过内皮的过渡性非稳态过程。基于在离体肺上获得的实验数据，提出了一个使用线性非平衡热力学方程描述非稳态现象的模型。流体流动由简单方程表征，如Kedem-Kachal'skiĭ型方程。内皮膜被视为由三种不同孔隙群体组成的半透屏障。该模型包括对间质空间的力学特性以及水肿发展过程中时间间质体积变化的考虑。此外，还考虑了从间质到肺空气空间的流体流动。该模型的数值解与实验规律相符。
