Kumar Vinod Jangir, van Oort Erik, Scheffler Klaus, Beckmann Christian F, Grodd Wolfgang
Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands.
Neuroimage. 2017 Feb 15;147:678-691. doi: 10.1016/j.neuroimage.2016.12.071. Epub 2016 Dec 29.
In the present work, we used resting state-fMRI to investigate the functional anatomy of the thalamus at rest by applying an Independent Component Analysis to delineate thalamic substructures into stable and reproducible parcels for the left and right thalamus. We determined 15 functionally distinct thalamic parcels, which differed in laterality and size but exhibited a correspondence with 18 cytoarchitectonally defined nuclei. We characterized their structural connectivity in determining DWI based cortical fiber pathways and found selected projections to different cortical areas. In contrast, the functional connections of these parcels were not confined to certain cortical areas or lobes. We, finally evaluated cortical projections and found particular subcortical and cortical pattern for each parcel, which partly exhibited a correspondence with the thalamo-cortical connectivity maps of the mouse.
在本研究中，我们使用静息态功能磁共振成像（resting state-fMRI），通过应用独立成分分析（Independent Component Analysis）来描绘丘脑的亚结构，将左右丘脑划分为稳定且可重复的脑区，以研究静息状态下丘脑的功能解剖结构。我们确定了15个功能上不同的丘脑脑区，它们在左右侧性和大小上存在差异，但与18个细胞构筑学定义的核团相对应。我们在基于扩散加权成像（DWI）确定的皮质纤维束中表征了它们的结构连接性，并发现了投射至不同皮质区域的特定投射。相比之下，这些脑区的功能连接并不局限于特定的皮质区域或脑叶。最后，我们评估了皮质投射，发现每个脑区都有特定的皮质下和皮质模式，其中部分模式与小鼠的丘脑-皮质连接图谱相对应。
