Silva Dos Santos Priscilla de Nazaré, Madden Tessa, Omvig Karen, Peipert Jeffrey F
Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, Brazil; Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.
Division of Family Planning, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.
Contraception. 2017 Apr;95(4):382-389. doi: 10.1016/j.contraception.2016.12.006. Epub 2016 Dec 30.
Users of hormonal long-acting reversible contraception (LARC) report weight gain as a side effect, but few studies have assessed body composition change among LARC users. We evaluated weight and body composition of healthy women using the levonorgestrel intrauterine system (LNG-IUS), copper intrauterine device (copper IUD) or etonogestrel implant (ENG implant). We hypothesized that weight gain and body composition over 12 months would not differ between copper IUD, LNG-IUS and ENG implant users.
We performed a prospective cohort study of a subgroup of women enrolled in the Contraceptive CHOICE Project who initiated the LNG-IUS, copper IUD or ENG implant. Inclusion criteria included lack of metabolic and eating disorders or change in body weight of more than 5% in the 6 months before enrollment. We measured changes in weight and body composition (body fat percentage, total body fat mass, total lean mass and total body mass) in women who continued their method for 12 months.
We analyzed data from 149 participants: 85 LNG-IUS users, 31 copper IUD users and 33 ENG implant users. The mean age was 25.9 years, 56.4% were White, 82.5% had some college education and 67.6% were nulliparous. Although lean body mass increased over 12 months in LNG-IUS and copper IUD users but not in ENG implant users, changes in body weight and body composition did not differ between the groups. In the adjusted model, Black race was associated with change in total body mass (p<.05).
Among those who continued the method for 12 months, changes in body weight and composition did not differ between copper IUD, LNG-IUS and ENG implant users.
Changes in body weight and composition over 12 months did not differ between copper IUD users and LNG-IUS and ENG implant users among those with 12 months of continuous use.
长效可逆激素避孕法（LARC）的使用者称体重增加是一种副作用，但很少有研究评估LARC使用者的身体成分变化。我们评估了使用左炔诺孕酮宫内节育系统（LNG-IUS）、铜宫内节育器（铜IUD）或依托孕烯植入剂（ENG植入剂）的健康女性的体重和身体成分。我们假设，在12个月内，铜IUD、LNG-IUS和ENG植入剂使用者的体重增加和身体成分变化没有差异。
我们对参与避孕选择项目并开始使用LNG-IUS、铜IUD或ENG植入剂的女性亚组进行了一项前瞻性队列研究。纳入标准包括在入组前6个月内没有代谢和饮食紊乱或体重变化超过5%。我们测量了持续使用该方法12个月的女性的体重和身体成分变化（体脂百分比、全身脂肪量、总瘦体重和总体重）。
我们分析了149名参与者的数据：85名LNG-IUS使用者、31名铜IUD使用者和33名ENG植入剂使用者。平均年龄为25.9岁，56.4%为白人，82.5%接受过一些大学教育，67.6%为未生育女性。尽管LNG-IUS和铜IUD使用者的瘦体重在12个月内有所增加，但ENG植入剂使用者没有增加，但各组之间的体重和身体成分变化没有差异。在调整模型中，黑人种族与总体重变化相关（p<0.05）。
在持续使用该方法12个月的人群中，铜IUD、LNG-IUS和ENG植入剂使用者的体重和身体成分变化没有差异。
在持续使用12个月的人群中，铜IUD使用者与LNG-IUS和ENG植入剂使用者在12个月内的体重和身体成分变化没有差异。
