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本文引用的文献

1
Neuron-Specific Enolase as a Predictor of Death or Poor Neurological Outcome After Out-of-Hospital Cardiac Arrest and Targeted Temperature Management at 33°C and 36°C.神经元特异性烯醇化酶作为院外心脏骤停后目标温度管理在 33°C 和 36°C 时死亡或不良神经结局的预测因子。
J Am Coll Cardiol. 2015 May 19;65(19):2104-14. doi: 10.1016/j.jacc.2015.03.538.
2
Neurologic outcomes and postresuscitation care of patients with myoclonus following cardiac arrest.心脏骤停后肌阵挛患者的神经转归和复苏后护理。
Crit Care Med. 2015 May;43(5):965-72. doi: 10.1097/CCM.0000000000000880.
3
Neuron-specific enolase serum levels predict severe neuronal injury after extracorporeal life support in resuscitation.神经元特异性烯醇化酶血清水平可预测复苏后体外生命支持期间的严重神经元损伤。
Eur J Cardiothorac Surg. 2014 Mar;45(3):496-501. doi: 10.1093/ejcts/ezt370. Epub 2013 Jul 21.
4
Serum neuron-specific enolase levels from the same patients differ between laboratories: assessment of a prospective post-cardiac arrest cohort.不同实验室检测同一患者的血清神经元特异性烯醇化酶水平存在差异：一项前瞻性心脏停搏后队列研究评估。
Neurocrit Care. 2013 Oct;19(2):161-6. doi: 10.1007/s12028-013-9867-5.
5
Changes in neuron-specific enolase are more suitable than its absolute serum levels for the prediction of neurologic outcome in hypothermia-treated patients with out-of-hospital cardiac arrest.在接受低温治疗的院外心脏骤停患者中，神经元特异性烯醇化酶的变化比其血清绝对水平更适合用于预测神经功能预后。
Neurocrit Care. 2014 Jun;20(3):358-66. doi: 10.1007/s12028-013-9848-8.
6
Prognosis of coma after cardiac arrest in the era of hypothermia.低温时代心脏骤停后昏迷的预后
Continuum (Minneap Minn). 2012 Jun;18(3):515-31. doi: 10.1212/01.CON.0000415425.68900.c6.
7
Neurologic prognosis in cardiac arrest patients treated with therapeutic hypothermia.治疗性低温治疗的心脏骤停患者的神经预后
Neurologist. 2011 Sep;17(5):241-8. doi: 10.1097/NRL.0b013e318224ee0e.
8
Neurological injury in adults treated with extracorporeal membrane oxygenation.接受体外膜肺氧合治疗的成人的神经损伤
Arch Neurol. 2011 Dec;68(12):1543-9. doi: 10.1001/archneurol.2011.209. Epub 2011 Aug 8.
9
Hemolysis during cardiac extracorporeal membrane oxygenation: a case-control comparison of roller pumps and centrifugal pumps in a pediatric population.体外膜肺氧合治疗期间的溶血：儿童人群中滚压泵和离心泵的病例对照比较。
ASAIO J. 2011 Sep-Oct;57(5):456-61. doi: 10.1097/MAT.0b013e31822e2475.
10
Neuron-specific enolase correlates with other prognostic markers after cardiac arrest.神经元特异性烯醇化酶与心脏骤停后其他预后标志物相关。
Neurology. 2011 Aug 16;77(7):623-30. doi: 10.1212/WNL.0b013e31822a276d. Epub 2011 Jul 20.

体外膜肺氧合时代心脏骤停的神经学预后评估

Neurological Prognostication of Cardiac Arrest in an Era of Extracorporeal Membrane Oxygenation.

作者信息

Sahai Supreet K, Majic Tamara, Patel Jignesh, Nurok Michael, Moheet Asma M, Rosengart Axel J, Lahiri Shouri

机构信息

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Cedars-Sinai Medical Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.

出版信息

Neurohospitalist. 2017 Jan;7(1):35-38. doi: 10.1177/1941874416648195. Epub 2016 May 11.

DOI:10.1177/1941874416648195
PMID:28042368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5167091/
Abstract

A neuron-specific enolase level greater than 33 ng/mL at days 1 to 3 or status myoclonus within 1 day are traditional indicators of poor neurological prognosis in survivors of cardiac arrest. We report the case of a 70-year-old man who received extracorporeal membrane oxygenation following cardiac arrest. Despite having both an elevated neuron-specific enolase concentration of 68 ng/mL and status myoclonus, he made an excellent neurological recovery. The value of traditional markers of poor prognosis such as elevated neuron-specific enolase or status myoclonus has not been systematically validated in patients treated with extracorporeal membrane oxygenation or therapeutic hypothermia. Straightforward application of practice guidelines in these cases may result in tragic outcomes. This case underscores the need for reliable prognostic markers that account for recent advances in cardiopulmonary and neurological therapies.

摘要

心脏骤停幸存者中，第1至3天神经元特异性烯醇化酶水平大于33 ng/mL或1天内出现肌阵挛状态是神经功能预后不良的传统指标。我们报告了一例70岁男性在心脏骤停后接受体外膜肺氧合治疗的病例。尽管他的神经元特异性烯醇化酶浓度升高至68 ng/mL且存在肌阵挛状态，但他的神经功能恢复良好。在接受体外膜肺氧合或治疗性低温治疗的患者中，神经元特异性烯醇化酶升高或肌阵挛状态等预后不良传统标志物的价值尚未得到系统验证。在这些病例中直接应用实践指南可能会导致悲剧性后果。该病例强调了需要有可靠的预后标志物，以考虑到心肺和神经治疗方面的最新进展。