Lippi Giuseppe, Adcock Dorothy, Simundic Ana-Maria, Tripodi Armando, Favaloro Emmanuel J
a Section of Clinical Biochemistry, University of Verona , Verona , Italy.
b Colorado Coagulation, Laboratory Corporation of America® Holdings , Englewood , CO , USA.
Ann Med. 2017 Sep;49(6):455-461. doi: 10.1080/07853890.2016.1278303. Epub 2017 Feb 10.
The term "critical values" can be defined to entail laboratory test results that significantly lie outside the normal (reference) range and necessitate immediate reporting to safeguard patient health, as well as those displaying a highly and clinically significant variation compared to previous data. The identification and effective communication of "highly pathological" values has engaged the minds of many clinicians, health care and laboratory professionals for decades, since these activities are vital to good laboratory practice. This is especially true in hemostasis, where a timely and efficient communication of critical values strongly impacts patient management. Due to the heterogeneity of available data, this paper is hence aimed to analyze the state of the art and provide an expert opinion about the parameters, measurement units and alert limits pertaining to critical values in hemostasis, thus providing a basic document for future consultation that assists laboratory professionals and clinicians alike. KEY MESSAGES Critical values are laboratory test results significantly lying outside the normal (reference) range and necessitating immediate reporting to safeguard patient health. A broad heterogeneity exists about critical values in hemostasis worldwide. We provide here an expert opinion about the parameters, measurement units and alert limits pertaining to critical values in hemostasis.
“危急值”这一术语可定义为实验室检测结果显著超出正常（参考）范围，需要立即报告以保障患者健康，以及与先前数据相比显示出高度临床显著差异的结果。几十年来，“高度病理”值的识别和有效沟通一直是许多临床医生、医疗保健和实验室专业人员关注的问题，因为这些活动对于良好的实验室实践至关重要。在止血领域尤其如此，危急值的及时有效沟通对患者管理有很大影响。由于现有数据的异质性，本文旨在分析当前的技术水平，并就止血领域危急值的参数、测量单位和警报限提供专家意见，从而为未来的参考提供一份基础文件，以协助实验室专业人员和临床医生。关键信息：危急值是显著超出正常（参考）范围且需要立即报告以保障患者健康的实验室检测结果。全球范围内，止血领域的危急值存在广泛的异质性。我们在此提供关于止血领域危急值的参数、测量单位和警报限的专家意见。
