甲状腺激素水平与吉兰-巴雷综合征的频率和严重程度相关。
Thyroid hormone level is associated with the frequency and severity of Guillain-Barré syndrome.
作者信息
Huang Yuanyuan, Ying Zhaojian, Chen Zhibo, Xiang Weiwei, Su Zhongqian, Quan Weiwei, Weng Yiyun, Zhang Xu
机构信息
a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
b Department of Respiratory and Critical Care Medicine , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
出版信息
Int J Neurosci. 2017 Oct;127(10):893-899. doi: 10.1080/00207454.2016.1278541. Epub 2017 Jan 16.
OBJECTIVE
Guillain-Barré syndrome (GBS) is a neurodegenerative and inflammatory demyelination disorder, and oxidative stress is concerned with the pathogenesis of the disease. Also, we found that thyroid hormone level is correlated to the oxidative and antioxidant status in previous studies. Our study was aimed to find the possible relationship between the frequency and severity of GBS and thyroid hormone levels.
MATERIALS AND METHODS
We measured serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT) and free triiodothyronine (FT) in 238 individuals, including 90 GBS, 44 multiple sclerosis and 104 healthy controls.
RESULTS
Our findings demonstrate that the patients with GBS had lower TSH and higher FT FT/FT than healthy controls in the normal range. Furthermore, it was also shown in our study that TSH levels in patients with GBS were correlated with disease severity measured by the Hughes Functional Grading Scale.
CONCLUSION
Lower TSH, higher FT and FT/FT stand for the oxidative status and are associated with the incidence and severity of GBS.
目的
吉兰 - 巴雷综合征（GBS）是一种神经退行性和炎性脱髓鞘疾病，氧化应激与该疾病的发病机制有关。此外，我们在先前的研究中发现甲状腺激素水平与氧化和抗氧化状态相关。我们的研究旨在寻找GBS的频率和严重程度与甲状腺激素水平之间的可能关系。
材料与方法
我们测量了238名个体的血清促甲状腺激素（TSH）、游离甲状腺素（FT）和游离三碘甲状腺原氨酸（FT）水平，其中包括90例GBS患者、44例多发性硬化症患者和104名健康对照者。
结果
我们的研究结果表明，GBS患者的TSH水平较低，FT、FT/FT在正常范围内高于健康对照者。此外，我们的研究还表明，GBS患者的TSH水平与通过休斯功能分级量表测量的疾病严重程度相关。
结论
较低的TSH、较高的FT和FT/FT代表氧化状态，并且与GBS的发病率和严重程度相关。
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