Marvin Shauna A
Biology Department, Drake University, Des Moines, IA 50311, USA.
Viruses. 2016 Dec 30;9(1):1. doi: 10.3390/v9010001.
Astroviruses are one of the leading causes of pediatric gastroenteritis worldwide and are clinically importantly pathogens in the elderly and immunocompromised populations. Although the use of cell culture systems and small animal models have enhanced our understanding of astrovirus infection and pathogenesis, little is known about the immune response to astrovirus infection. Studies from humans and animals suggest that adaptive immunity is important in restricting classic and novel astrovirus infections, while studies from animal models and cell culture systems suggest that an innate immune system plays a role in limiting astrovirus replication. The relative contribution of each arm of the immune system in restricting astrovirus infection remains unknown. This review summarizes our current understanding of the immune response to astrovirus infection and highlights some of the key questions that stem from these studies. A full understanding of the immune response to astrovirus infection is required to be able to treat and control astrovirus-induced gastroenteritis.
星状病毒是全球小儿肠胃炎的主要病因之一，也是老年人和免疫功能低下人群中具有重要临床意义的病原体。尽管细胞培养系统和小动物模型的应用增进了我们对星状病毒感染及发病机制的理解，但对于星状病毒感染的免疫反应却知之甚少。来自人类和动物的研究表明，适应性免疫在限制经典和新型星状病毒感染中很重要，而来自动物模型和细胞培养系统的研究表明，先天免疫系统在限制星状病毒复制中发挥作用。免疫系统各分支在限制星状病毒感染中的相对贡献仍不清楚。本综述总结了我们目前对星状病毒感染免疫反应的理解，并强调了这些研究中产生的一些关键问题。为了能够治疗和控制星状病毒引起的肠胃炎，需要全面了解对星状病毒感染的免疫反应。
