Marcó Núria, Gil Roberto R, Parella Teodor
Servei de Ressonància Magnètica Nuclear and Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Barcelona), Catalonia, Spain.
Department of Chemistry, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, PA, 15213, USA.
Magn Reson Chem. 2017 Jun;55(6):540-545. doi: 10.1002/mrc.4575. Epub 2017 Feb 8.
A fast residual dipolar coupling constant-assisted strategy involving the simultaneous determination of scalar and total coupling constants from a single J / J -resolved NMR spectrum is reported. It is shown that the concerted use of the directly measured D (for all CH multiplicities) and D residual dipolar couplings allows an on-the-fly assignment of diastereotopic CH protons, as well as of an efficient discrimination between diastereoisomeric structures of strychnine which contains six stereocenters. Copyright © 2017 John Wiley & Sons, Ltd.
报道了一种快速的残余偶极耦合常数辅助策略，该策略涉及从单个J/J分辨核磁共振谱中同时测定标量耦合常数和总耦合常数。结果表明，协同使用直接测量的D（针对所有CH多重性）和D残余偶极耦合能够即时对非对映异位CH质子进行归属，同时也能有效区分含有六个立体中心的士的宁的非对映异构体结构。版权所有© 2017约翰·威利父子有限公司。
