Kanonov A V, Nepomniashchikh L M, Predvechnaia I K, Nepomniashchikh G I
Biull Eksp Biol Med. 1989 Aug;108(8):247-50.
By methods of immunohistochemistry, light and electron microscopies gastrobiopsies from regions of acute and chronic erosions and border zones of gastric mucosa were studied in 36 patients with erosive gastritis. There was determined the decrease of amount of IgA-producing cells against a background of the increase of IgG-producing plasmocytes in the zone of mucosal defect. IgG-precipitations and fixation of heterogeneous complement in fibrinoid necrosis of erosive defect were revealed. Mucosal microcirculatory disturbances stipulated by immunocomplex injuries are found to be mosaic. There is given proof of the role of second local immunity disturbances in origin and chronization of erosive defects of gastric mucosa.
采用免疫组织化学、光镜和电镜方法，对36例糜烂性胃炎患者胃黏膜急性和慢性糜烂区域及边界区的胃活检组织进行了研究。结果发现，在黏膜缺损区域，IgA产生细胞数量减少，而产生IgG的浆细胞数量增加。在糜烂缺损的纤维蛋白样坏死中发现了IgG沉淀和异源性补体的固定。由免疫复合物损伤引起的黏膜微循环障碍呈镶嵌状。有证据表明，局部免疫二次紊乱在胃黏膜糜烂缺损的发生和慢性化过程中起作用。
