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耐多药结核病的胸外科手术干预措施及其效果。

Thoracic surgical interventions for DR-TB and their results.

作者信息

Dewan Ravindra Kumar

机构信息

Department of Thoracic Surgery, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.

出版信息

Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S55. doi: 10.1016/j.ijmyco.2016.11.024. Epub 2016 Nov 27.

Abstract

BACKGROUND

Surgery in DR-TB is a highly contested intervention. However, in suitable selected cases, it has a great role in improving outcomes of treatment as well as symptomatic improvement in the quality of life of the patient. Indications of surgery in this setting will be localized disease with high likelihood of persistent progression or sputum positivity despite adequate therapy. Recurrent hemoptysis, intolerance to drugs or absence of radiological and bacteriological improvement during initial 3-4months of therapy becomes additional indications for surgical intervention. A review of 11 studies published in a period from 1993 to 2013 provides enough justification for the role of surgical intervention in pulmonary tuberculosis.

INTERVENTIONS

At the NITRD, in the last 20years a total of 107 cases have been operated upon for DR-TB. Procedures done were 70 pneumonectomies, 20 lobectomies, 5 bilobectomies, 4 nonanatomical resections and 7 thoracoplasties.

RESULTS

Sputum negativity was achieved in 93 cases after surgery and 62 were declared cured after 4years of follow up. 6 cases of DR TB were also operated upon in March 2013 in one MSF TB surgery mission and all of them are sputum negative till March 2015.

CONCLUSIONS

In conclusion, surgical intervention should be offered and made available for greater number of DR-TB patients.

摘要

背景

耐多药结核病的手术治疗是一项极具争议的干预措施。然而,在经过适当挑选的病例中,手术对于改善治疗效果以及患者生活质量的症状改善具有重要作用。在此情况下,手术适应症为尽管接受了充分治疗但仍有持续进展或痰菌阳性可能性较高的局限性疾病。反复咯血、对药物不耐受或在治疗最初3 - 4个月期间影像学和细菌学无改善成为手术干预的额外适应症。对1993年至2013年期间发表的11项研究的综述为手术干预在肺结核治疗中的作用提供了充分的依据。

干预措施

在国家结核病研究所(NITRD),过去20年中共有107例耐多药结核病患者接受了手术治疗。所实施的手术包括70例全肺切除术、20例肺叶切除术、5例双肺叶切除术、4例非解剖性切除术和7例胸廓成形术。

结果

93例患者术后痰菌转阴,62例在随访4年后被宣布治愈。2013年3月,在一个无国界医生组织的结核病手术任务中,6例耐多药结核病患者也接受了手术治疗,截至2015年3月,所有患者痰菌均为阴性。

结论

总之,应向更多的耐多药结核病患者提供并使其能够接受手术干预。

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