突破第一道谱系屏障——滋养层干细胞命运的多种途径。

Breaking the first lineage barrier - many roads to trophoblast stem cell fate.

机构信息

Department of Developmental Pathology, Institute of Pathology, Bonn Medical School, 53127 Bonn, Germany.

出版信息

Placenta. 2017 Dec;60 Suppl 1:S52-S56. doi: 10.1016/j.placenta.2016.12.025. Epub 2016 Dec 23.

DOI:10.1016/j.placenta.2016.12.025

Abstract

Recently, direct cell fate conversion attempts between the embryonic and extra-embryonic lineage gained new momentum. Two concomitant publications were published, describing the successful generation of transgene-independent, self-renewing trophoblast stem cells (TSCs) from murine fibroblasts. Cells were faithfully converted, displaying high similarity to blastocyst or extraembryonic ectoderm derived TSCs. Here, we summarize and compare published attempts aiming at the direct induction of trophoblast-fate from either mouse embryonic stem cells or fibroblasts.

摘要

最近，在胚胎和胚胎外谱系之间进行直接细胞命运转换的尝试获得了新的动力。两篇同时发表的论文描述了成功地从小鼠成纤维细胞中产生了非转基因、自我更新的滋养层干细胞（TSC）。这些细胞被忠实地转化，表现出与囊胚或胚胎外外胚层衍生的 TSC 高度相似。在这里，我们总结并比较了旨在直接从小鼠胚胎干细胞或成纤维细胞诱导滋养层命运的已发表尝试。