糖尿病角膜中的神经元变化：神经保护的前景
Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection.
作者信息
Bikbova Guzel, Oshitari Toshiyuki, Baba Takayuki, Yamamoto Shuichi
机构信息
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670, Japan.
出版信息
Biomed Res Int. 2016;2016:5140823. doi: 10.1155/2016/5140823. Epub 2016 Dec 1.
Abstract
Diabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregularity. This review presents recent findings on impaired corneal innervation in diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy. Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic keratopathy are presented.
摘要
糖尿病性神经病变与皮肤和角膜的神经营养性溃疡有关。角膜敏感性降低和神经支配受损导致上皮伤口愈合减弱，使患者易患眼部并发症，如角膜感染、基质混浊和表面不规则。本文综述了糖尿病患者角膜神经支配受损的最新研究结果，这些结果表明角膜神经病变可能是糖尿病性神经病变的早期指标。此外，还介绍了糖尿病性角膜病变神经保护和再生治疗的最新研究结果。
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