Vandeputte D, Van Grieken R E, Jacob W A, Savory J, Bertholf R L, Wills M R
Department of Medicine, University of Antwerp, UIA, Antwerp-Wilrijk, Belgium.
Biomed Environ Mass Spectrom. 1989 Aug;18(8):598-602. doi: 10.1002/bms.1200180815.
By means of laser microprobe mass analysis (LAMMA), we have studied the ultrastructural localization of aluminium in livers of aluminium maltol-treated rabbits. This animal model was developed to study long-term aluminium toxicity using systemic (intravenous) administration of aluminium. We could only detect aluminium in electron-dense inclusion bodies found in large, sometimes multinucleated cells. These results prove that the actual observation of aluminium deposits in liver with LAMMA gives more information than bulk analysis and can be very useful to explore mechanisms of toxicity.
通过激光微探针质谱分析（LAMMA），我们研究了用麦芽醇铝处理的兔子肝脏中铝的超微结构定位。开发这种动物模型是为了通过全身（静脉）注射铝来研究长期铝毒性。我们仅在大型（有时为多核）细胞中的电子致密包涵体中检测到铝。这些结果证明，用LAMMA实际观察肝脏中的铝沉积物比整体分析能提供更多信息，并且对于探索毒性机制非常有用。
