Zyngier S, Kimura E, Najjar R
Departamento de Farmacologia, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1989;22(3):397-401.
Rhodium II citrate was tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and inhibition of DNA synthesis by Ehrlich tumor, malignant adrenocortical cells (Y-1) and normal adrenocortical cells (AR-1). At ip doses up to 260 mg/kg, the compound had no toxic effects for up to 14 days. The same total dose given over 4 days significantly increased the survival rate of mice bearing Ehrlich ascites cells. Thymidine incorporation by Ehrlich tumor, Y-1 and AR-1 cells in vitro was inhibited 50% by 0.1 to 0.2 mM concentrations of the compound. We conclude that the increased survival of the tumor-bearing mice was due at least in part to the inhibition of DNA synthesis with a consequent reduction of cell division and tumor growth.
对柠檬酸铑 II 在小鼠身上进行了急性毒性、对艾氏腹水癌的抗肿瘤活性以及对艾氏瘤、恶性肾上腺皮质细胞（Y - 1）和正常肾上腺皮质细胞（AR - 1）DNA 合成抑制作用的测试。腹腔注射剂量高达 260 mg/kg 时，该化合物在长达 14 天内无毒性作用。在 4 天内给予相同的总剂量显著提高了携带艾氏腹水细胞小鼠的存活率。在体外，0.1 至 0.2 mM 浓度的该化合物可抑制艾氏瘤、Y - 1 和 AR - 1 细胞掺入胸苷达 50%。我们得出结论，荷瘤小鼠存活率的提高至少部分归因于 DNA 合成的抑制，从而导致细胞分裂和肿瘤生长的减少。
