Crabbe K
Bull Mem Acad R Med Belg. 1989;144(1-2):176-86; discussion 186-7.
Aldosterone as a regulatory factor of extracellular volumes: mechanism of action. The key role assumed by aldosterone in the regulation of extracellular volumes, requires that chloride move along with sodium when active transport of the latter ion is stimulated. In the mammalian nephron, aldosterone promotes reabsorption of sodium by the principal cells of the cortical portion of the collecting duct. This results from hormone-induced increase in conductance for sodium at the apical role of the target cells, and later on, from associated increased density of the sodium "pump" units at the basolateral pole. Studies carried out on amphibian epithelia indicate that chloride permeability-of mitochondria-rich cells, and in all likelihood--is concurrently increased by aldosterone. It therefore looks as though this steroid hormone influences in a concerted way two cell populations, one being involved in transepithelial sodium transport, the other one representing the route of passage for the accompanying anion.
作用机制。醛固酮在细胞外液量调节中所起的关键作用，要求在刺激钠离子主动转运时，氯离子与钠离子一起移动。在哺乳动物肾单位中，醛固酮促进集合管皮质部主细胞对钠的重吸收。这是由于激素诱导靶细胞顶端膜对钠的电导率增加，随后是基底外侧极钠“泵”单位相关密度增加所致。对两栖类上皮的研究表明，醛固酮同时增加了富含线粒体细胞的氯离子通透性。因此，这种类固醇激素似乎以协同方式影响两个细胞群体，一个参与跨上皮钠转运，另一个是伴随阴离子的通道。
