Sauvé William M
TMS NeuroHealth Centers of Richmond and Charlottesville,Glen Allen and Charlottesville,Virginia,USA.
CNS Spectr. 2016 Dec;21(S1):34-44. doi: 10.1017/S1092852916000791.
Pseudobulbar affect, thought by many to be a relatively newly described condition, is in fact a very old one, described as early as the 19th century. It refers to those who experience inappropriate affect, disconnected from internal state, or mood, generally thought to be the result of an upper motor neuron injury or illness. One possible explanation for this condition's relative obscurity is the dearth of treatment options; clinical medicine is not typically in the habit of identifying conditions that cannot be modified. Now, however, there is good evidence for the treatment of pseudobulbar affect, and even a therapy approved for use by the U.S. Food and Drug Administration (FDA). As a result, appropriate identification and subsequent management of pseudobulbar affect is more important than ever. This article purports to summarize the origins of pseudobulbar affect, most current hypotheses as to its physiopathology, clinical identification, and evidence for management.
许多人认为假性球麻痹是一种相对较新描述的病症，实际上它是一种非常古老的病症，早在19世纪就有描述。它指的是那些经历不适当情感反应的人，这种情感反应与内在状态或情绪脱节，通常被认为是上运动神经元损伤或疾病的结果。这种病症相对不为人知的一个可能解释是治疗选择的匮乏；临床医学通常不习惯识别无法改变的病症。然而，现在有充分的证据证明可以治疗假性球麻痹，甚至有一种疗法已获美国食品药品监督管理局（FDA）批准使用。因此，对假性球麻痹进行恰当识别并随后进行管理比以往任何时候都更加重要。本文旨在总结假性球麻痹的起源、关于其生理病理学的最新假说、临床识别方法以及管理依据。
