Fujisawa S, Imai Y, Masuhara E
Dtsch Zahnarztl Z. 1978 Oct;33(10):706-11.
For the biological examination of dental resin filling materials, a solubility and hemolysis test is recommended as an in-vitro testing method. Solubility and degree of hemolysis were examined in various filling materials based on MMA and BIS-GMA. It was found that, at the beginning, solubility was considerably higher in MMA-containing materials than in the BIS-GMA systems, and that after a while the conditions were reversed. The degree of hemolysis decreased in the following order with the individual materials: 1. Posite, Sevriton, Adatpic, 2. Epoxylite, Smile, Palakav, 3. MMA-BPO/Amin and MMA-TBBO. Comparison between the MMA and BIS-GMA monomers showed that corresponding to the same molar amounts, BIS-GMA materials developed a higher degree of hemolysis.
对于牙科树脂填充材料的生物学检测，建议采用溶解度和溶血试验作为体外检测方法。基于甲基丙烯酸甲酯（MMA）和双酚A缩水甘油醚甲基丙烯酸酯（BIS-GMA），对各种填充材料的溶解度和溶血程度进行了检测。结果发现，起初，含MMA的材料的溶解度明显高于BIS-GMA体系的材料，一段时间后情况则相反。不同材料的溶血程度按以下顺序降低：1. Posite、Sevriton、Adatpic；2. Epoxylite、Smile、Palakav；3. MMA-BPO/胺和MMA-TBBO。MMA和BIS-GMA单体之间的比较表明，在相同摩尔量的情况下，BIS-GMA材料产生的溶血程度更高。
