Jordahl Jacob H, Ramcharan Stacy, Gregory Jason V, Lahann Joerg
Biointerfaces Institute, Department of Chemical Engineering, University of Michigan, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA.
Department of Biomedical Engineering, Material Science and Engineering, and Macromolecular Science and Engineering, University of Michigan, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA.
Macromol Rapid Commun. 2017 Jan;38(1). doi: 10.1002/marc.201600437. Epub 2016 Nov 7.
Electrohydrodynamic cojetting can result in fibers (electrospinning) and particles (electrospraying) with complex, bicompartmental architectures. An important consideration for application of bicompartmental particles and fibers is the limited throughput derived from the use of parallel capillaries, which require laminar flow to form a multifluidic interface. Here, a novel synthesis approach that takes advantage of an extended bicompartmental fluid interface formed at the sharp edge of a 2D plate is reported. Upon application of an electrical potential to the plate, several electrified fluid jets form spontaneously. Depending on the processing conditions, either bicompartmental particles or fibers with well-defined architectures are prepared. Importantly, this needleless process yields production rates that are more than 30 times higher than those of conventional needle-based techniques. Fiber properties, such as morphology or size, are independent of the flow rate, indicating that this process is physically self-regulating by adjusting the number of jets ejecting from the extended fluid interface. The needleless preparation of bicompartmental particles and fibers is an important technological breakthrough that can enable further advances ranging from drug delivery and tissue engineering to industrial applications.
电流体动力学共喷射可产生具有复杂双隔室结构的纤维（静电纺丝）和颗粒（电喷雾）。双隔室颗粒和纤维应用中的一个重要考虑因素是使用平行毛细管导致的通量有限，平行毛细管需要层流来形成多流体界面。在此，报道了一种新颖的合成方法，该方法利用在二维平板尖锐边缘形成的扩展双隔室流体界面。向平板施加电势后，会自发形成多个带电流体射流。根据加工条件，可制备出具有明确结构的双隔室颗粒或纤维。重要的是，这种无针工艺的生产率比传统基于针的技术高出30多倍。纤维特性，如形态或尺寸，与流速无关，这表明该工艺通过调整从扩展流体界面喷出的射流数量进行物理自调节。双隔室颗粒和纤维的无针制备是一项重要的技术突破，可为从药物递送、组织工程到工业应用等领域带来进一步进展。
