Trubin Paul A, Edward Justin A, Hand Monica
Tulane University Health Sciences Center, department of internal medicine - New Orleans, LA.
J La State Med Soc. 2016 Nov-Dec;168(6):196-200. Epub 2016 Dec 15.
As a subset of microangiopathic hemolytic anemia, thrombotic thrombocytopenic purpura can present with a constellation of symptoms similar to the hemolytic anemia attributed to severe vitamin B12 deficiency. There have been few case reports in the medical literature concerning the development of a clinical syndrome consistent with microangiopathic hemolytic anemia attributable to B12 deficiency. We report a case of B12 deficiency leading to microangiopathic hemolytic anemia that was corrected solely with a ten-day course of intramuscular cobalamin replacement. Prompt diagnostic and clinical evaluation utilizing specific exclusion parameters can promote accurate and safe treatment of the clinical syndrome of microangiopathic hemolytic anemia related to B12 deficiency.
作为微血管病性溶血性贫血的一个子集，血栓性血小板减少性紫癜可能表现出一系列类似于严重维生素B12缺乏所致溶血性贫血的症状。医学文献中关于由B12缺乏引起的符合微血管病性溶血性贫血的临床综合征的病例报告很少。我们报告一例B12缺乏导致微血管病性溶血性贫血的病例，该病例仅通过为期十天的肌肉注射钴胺素替代治疗就得到了纠正。利用特定的排除参数进行及时的诊断和临床评估，可以促进对与B12缺乏相关的微血管病性溶血性贫血临床综合征的准确和安全治疗。
