乳腺癌迟发性脉络膜转移
LATE-ONSET CHOROIDAL METASTASIS FROM BREAST CANCER.
作者信息
Levison Ashleigh L, Erenler Feyza, Zhao Yue, Martin Daniel F, Lowder Careen, Budd G Thomas, Singh Arun D
机构信息
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio.
出版信息
Retin Cases Brief Rep. 2018;12(4):342-345. doi: 10.1097/ICB.0000000000000516.
PURPOSE
Report occurrence of late-onset choroidal metastasis from breast cancer.
METHODS
Retrospective chart review.
RESULTS
The authors report 3 patients with choroidal metastasis from breast cancer that presented more than 20 years after diagnosis of the primary tumor. The choroidal metastases were the presenting feature of metastatic disease in all three patients, but after imaging, all patients had metastasis elsewhere as well. Two of the patients' tumors were known, ER+, and the hormone receptor status of the third patient was unknown. All three patients were treated with aromatase inhibitors with good response.
CONCLUSION
Late onset of metastatic disease, an excellent response to hormonal therapy, and a prolonged survival despite presence of systemic disease suggests a milder variant within the broad category of breast cancer patients with uveal metastases. Awareness of this entity can minimize the risk of misdiagnosis and avoid potentially toxic local therapy.
目的
报告乳腺癌迟发性脉络膜转移的发生情况。
方法
回顾性病历审查。
结果
作者报告了3例乳腺癌脉络膜转移患者，这些转移在原发性肿瘤诊断20多年后出现。脉络膜转移是所有3例患者转移性疾病的首发特征，但经影像学检查后，所有患者在其他部位也有转移。其中2例患者的肿瘤已知为雌激素受体阳性（ER+），第3例患者的激素受体状态未知。所有3例患者均接受芳香化酶抑制剂治疗，反应良好。
结论
转移性疾病迟发、对激素治疗反应良好以及尽管存在全身性疾病但生存期延长，提示在患有葡萄膜转移的乳腺癌患者这一广泛类别中存在一种较温和的变体。认识到这一实体可将误诊风险降至最低，并避免潜在的毒性局部治疗。
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