Zhang Yang, Li Zongjuan, Zhang Jian, Li Hongsheng, Qiao Yumei, Huang Chengsuo, Li Baosheng
School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong province, China.
Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong province, China.
PLoS One. 2017 Jan 3;12(1):e0169147. doi: 10.1371/journal.pone.0169147. eCollection 2017.
Reactive oxygen species (ROS), formed as an indirect production of radiotherapy (RT), could cause DNA damage of normal tissues. Meanwhile, our body possesses the ability to restore the damage by DNA repair pathways. The imbalance between the two systems could finally result in radiation injury. Therefore, in this prospective cohort study, we explored the association of genetic variants in ROS metabolism and DNA repair pathway-related genes with radiation pneumonitis (RP). A total of 265 locally advanced esophageal squamous cell carcinoma (ESCC) patients receiving RT in Chinese Han population were enrolled. Five functional single nucleotide polymorphisms (SNPs) (rs1695 in GSTP1; rs4880 in SOD2; rs3957356 in GSTA1; and rs1801131, rs1801133 in MTHFR) were genotyped using the MassArray system, and rs1801131 was found to be a predictor of ≥ 2 RP. Our results showed that, compared with TT genotype, patients with GG/GT genotypes of rs1801131 had a notably lower risk of developing ≥ 2 RP (HR = 0.339, 95% CI = 0.137-0.839, P = 0.019). Further independent studies are required to confirm this findings.
作为放射治疗（RT）的间接产物形成的活性氧（ROS）可导致正常组织的DNA损伤。同时，我们的身体具有通过DNA修复途径修复损伤的能力。这两个系统之间的失衡最终可能导致放射损伤。因此，在这项前瞻性队列研究中，我们探讨了ROS代谢和DNA修复途径相关基因的遗传变异与放射性肺炎（RP）之间的关联。共纳入了265名接受放疗的中国汉族局部晚期食管鳞状细胞癌（ESCC）患者。使用MassArray系统对五个功能性单核苷酸多态性（SNP）（GSTP1中的rs1695；SOD2中的rs4880；GSTA1中的rs3957356；以及MTHFR中的rs1801131、rs1801133）进行基因分型，发现rs1801131是≥2级RP的一个预测指标。我们的结果显示，与TT基因型相比，rs1801131的GG/GT基因型患者发生≥2级RP的风险显著降低（HR = 0.339，95%CI = 0.137 - 0.839，P = 0.019）。需要进一步的独立研究来证实这一发现。
