Shu Y D, Chang M K, Hsein H H
Zhonghua Yi Xue Za Zhi (Taipei). 1989 May;43(5):292-8.
In the routine analysis of patients with tremors, we have the routine analysis of patients with tremors, we have encountered three patients with severe cerebellar postural & kinetic tremors. Surface EMG study revealed alternating activity in antagonistic muscles with low frequency (3-5 cps) and wide duration (over 125msecs). They were different to typical essential tremor & parkinson's tremor in the clinical manifestation and tremogram. The tremor did not respond to high dose of propranolol (120-160mg/day), but responded to high dose of isoniazid (800-1200mg/day). Patients were evaluated before & after INH therapy with videotaping, surface EMG quantitative recording. One patient had transient side effects (abnormal liver function) in the beginning of treatment possibly because he was a "slow acetylator". The possible mechanism of effort of INH was discussed.
在对震颤患者的常规分析中，我们遇到了三名患有严重小脑姿势性和运动性震颤的患者。表面肌电图研究显示拮抗肌有交替活动，频率低（3 - 5次/秒）且持续时间长（超过125毫秒）。它们在临床表现和震颤图上与典型的特发性震颤和帕金森震颤不同。这种震颤对高剂量普萘洛尔（120 - 160毫克/天）无反应，但对高剂量异烟肼（800 - 1200毫克/天）有反应。在接受异烟肼治疗前后，通过录像、表面肌电图定量记录对患者进行了评估。一名患者在治疗开始时出现短暂的副作用（肝功能异常），可能是因为他是“慢乙酰化者”。讨论了异烟肼作用的可能机制。
