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[丁哌卡因在产科镇痛中的应用]

[The use of Marcaine in obstetrical analgesia].

作者信息

Seebacher J, Chareire F, Galli-Douant P, Viars P

出版信息

Ann Anesthesiol Fr. 1978;19(4):247-53.

PMID:28048
Abstract

Bupivacaine (Marcaine) is being used increasingly in obstetrics for epidural analgesia, by virtue of the good sensory block obtained and the minimum of side-effects on the mother and newborn infant. At a concentration of less than 0.5 p. 100, analgesia is excellent with a minimal effect on motor fibres. Side-effects and toxicity are limited by the use of fractionated doses from the beginning of labour or of a single dose during or at the end of labour calculated in relation to the effect sought. Any action on the newborn infant would appear to be exceptional, if dose recommendations are respected, the high percentage of Marcaine bound to proteins limiting its transplacental passage.

摘要

布比卡因(耐乐品)因其能产生良好的感觉阻滞,且对母婴的副作用最小,在产科越来越多地用于硬膜外镇痛。浓度低于0.5%时,镇痛效果极佳,对运动纤维的影响极小。通过从分娩开始时使用分次剂量或在分娩期间或结束时根据所需效果计算使用单次剂量,可限制副作用和毒性。如果遵循剂量建议,对新生儿的任何影响似乎都是例外情况,因为与蛋白质结合的布比卡因比例很高,限制了其经胎盘转运。

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